Iodinated porphyrins in contrast media agents: a new approach, first indicators
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منابع مشابه
Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice
Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed i...
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Iodinated contrast media (ICM) are commonly administered pharmaceutical agents. Most often they are used intravenously and intraarterially. Although iodinated contrast agents are relatively safe and widely used, adverse events occur and questions remain about their use, safety, and interactions. The most important adverse effects of contrast media include hypersensitivity reactions, thyroid dys...
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Long before humans roamed the planet, porphyrins in blood were serving not only as indispensable oxygen carriers, but also as the bright red contrast agent that unmistakably indicates injury sites. They have proven valuable as whole body imaging modalities have emerged, with endogenous hemoglobin porphyrins being used for new approaches such as functional magnetic resonance imaging and photoaco...
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Contrast media induced nephropathy (CIN) leading to acute renal failure is a rare event associated with iodinated contrast agents. Several studies published recently in Radiology (1-3) suggest the risk of contrast induced nephropathy (CIN) following intravenous iodinated contrast administration is much lower than previously believed. In this article we provide an update on recent revisions to o...
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Background Iodinated contrast media (ICM) are diagnostic agents used in millions of X-ray procedures yearly. Although current agents are usually well tolerated, mild immediate hypersensitivity reactions (IHR) occur in about 0.15% to 3% of administrations and severe IHRs in 0.01% to 0.04%. Despite this low incidence these reactions are an important clinical problem because the increasingly large...
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